Fri, November 20, 2009
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Fri, November 20, 2009
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| Associate Professor and Canada Research Chair in Environmental Toxicology Adjunct Associate Professor, University of Manitoba, Department of Chemistry Adjunct Associate Professor, University of Alberta, Department of Chemistry Degrees: Phone: (204) 786-9335 Teaching Specialties:ENV 2604/3 Environment and HealthCHEM 4301/6 Instrumental Analysis Research Interests:My research interests are in the area of environmental chemistry, and focus on elucidating the fate, behavior, and effects of anthropogenic compounds in the environment. A thorough understanding of how chemical pollutants move, react, and persist in the environment is crucial for finding solutions to the risks they may pose to the public, to wildlife, and to environmental resources. Of particular interest are chemicals that are widely produced and released as a result of human activity, and/or chemicals that bioaccumulate up aquatic and terrestrial food webs that are globally distributed from long-range transport. |
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A major area of research is the environmental chemistry of chiral organic pollutants. Many xenobiotic compounds are optically active: both legacy chemicals such as DDT, chlordanes and other chlorinated pesticides, and some PCB congeners; as well as current-use chemicals such as modern agrochemicals, pharmaceuticals and personal care products, and metabolites. Enantiomers of these chemicals generally undergo the same physical and chemical processes in the environment, but may have different biochemical and toxicological effects due to differential interactions with other chiral molecules (i.e., enzymes in living organisms). We have developed analytical techniques to measure enantiomeric composition of chiral pollutants in complex environmental compartments (e.g., natural waters, sediments, foods, biological tissues, waste streams) via chiral GC, multidimensional GC, HPLC, and capillary electrophoresis, usually coupled to mass spectrometric (MS or tandeom MS) detection for sensitivity and selectivity. These techniques are applied both in laboratory and field settings to understand stereoselective biotransformation and toxicological effects of chiral chemicals in the environment, and implications these may have on the ultimate fate of persistent pollutants. Another research area is the environmental occurrence and fate of emerging classes of environmental pollutants, including current-use agrochemicals, fluorinated surfactants, pharmaceuticals, personal care products, pollutant metabolites, and engineered nanomaterials. These chemicals are often heavily used in household or industrial applications, and may survive treatment when they are disposed and thus enter the environment. In general, little is known about the fate and transport of many such compounds, or of toxic effects. Our research interests for emerging pollutants include development of new and better techniques to measure these chemicals at trace concentrations of parts-per-trillion and below (e.g., passive sampling, microextraction) in very complex environmental matrices such as wastewaters, surface waters, and biological tissues. We also apply these techniques to understand environmental processes and effects of these compounds. Selected Publications:N. A. Warner, J. W. Martin, C. S. Wong, "Chiral polychlorinated biphenyls are biotransformed enantioselectively by mammalian cytochrome P-450 isozymes to form hydroxylated metabolites", Environ. Sci. Technol. 2009, 43, 114-121. hotlinkM. S. Ross, J. Verreault, R. J. Letcher, G. W. Gabrielsen, C. S. Wong, "Chiral organochlorine contaminants in blood and eggs of glaucous gulls (Larus hyperboreus) from the Norwegian Arctic", Environ. Sci. Technol.2008, 42, 7181-7186. hotlink S. L. MacLeod, P. Sudhir, C. S. Wong, "Stereoisomer analysis of wastewater-derived beta-blockers, selective serotonin re-uptake inhibitors, and salbutamol by high performance liquid chromatography-tandem mass spectrometry", J. Chromatogr. A 2007, 1170, 23-33. hotlink S. L. MacLeod, E. L. McClure, C. S. Wong, "Laboratory calibration and field deployment of the Polar Organic Chemical Integrative Sampler for pharmaceuticals and personal care products in wastewater and surface water." Environ. Toxicol. Chem. 2007, 26, 2517-2529. hotlink B. J. Asher, C. S. Wong, L. A. Rodenburg, "Chiral source apportionment of polychlorinated biphenyls to the Hudson River estuary atmosphere and food web", Environ. Sci. Technol. 2007, 41, 6163-6169. hotlink N. A. Warner, C. S. Wong, "The aquatic invertebrate Mysis relicta can eliminate chiral organochlorine compounds enantioselectively", Environ. Sci. Technol. 2006, 40, 4158-4164. hotlink A. H. Buckman, C. S. Wong, E. A. Chow, S. B. Brown, K. R. Solomon, A. T. Fisk, "Biotransformation of polychlorinated biphenyls (PCBs) and bioformation of hydroxylated PCBs in fish", Aquat. Toxicol. 2006, 78, 176-185. hotlink |
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