Department of Chemistry
The University of Winnipeg
599 Portage Avenue, Winnipeg
Manitoba, R3B 2E9 Canada
Phone: (204) 786-9083
Lab group website: http://ion.uwinnipeg.ca/~twood
Ph.D., Dalhousie University, 2007
NSERC Post-doctoral Fellow, Ontario Cancer Institute, 2007-2010
CHEM-2202(3) Organic Chemistry I
CHEM-2203(3) Organic Chemistry II
CHEM-3502(3) Intermediate Biochemistry I
CHEM-3503(3) Intermediate Biochemistry II
CHEM-4502(3) Molecular Enzymology
Our research interests lie in the area of organic synthetic methodology. The organic synthetic reaction that we study is an aryl migration reaction affiliated with the Truce-Smiles rearrangement. Our research involves exploring the nature of this reaction in terms of its mechanism, what kind of molecules it can accept as substrates, and what we can do to make it a reliable and predictable technology for use in the synthesis of new molecules. With this kind of information, we can investigate ways to apply the reaction to solving problems like making the production of difficult molecules easier, and accessing new molecules with interesting new properties.
Our other area of research interest is medicinal chemistry, specifically in the discovery of new small molecule cancer therapeutics. Often, adverse side effects are experienced by chemotherapy patients due to the indiscriminant cytotoxic activities of cancer drugs. Researchers have made excellent progress in creating targeted drugs for cancer chemotherapy, but there remains a great opportunity to develop new drugs that offer decreased side-effects while potently treating this diverse disease. Our research in this area involves using some established organic synthetic methods, as well as developing new organic reactions, for creating small libraries of new potential chemotherapeutic drugs. The molecules will not only be characterized for typical evidence of identity and purity, but also for specific biological activities. In doing so, we hope to gain a better understanding of the complex factors involved in targeting tumors over normal healthy tissue. Interdisciplinary research of this nature creates the opportunity for trainees to learn skills from the field of synthetic organic chemistry as well as biochemistry.
Recent Selected Publications:
Kosowan, J.R.; W’Giorgis, Z.; Grewal, R.; Wood, T.E. “Truce-Smiles rearrangement of substituted phenyl ethers” Organic & Biomolecular Chemistry 2015, 13, 6754-65.
Lundrigan, T.; Baker, A.E.G.; Longobardi, L.E.; Wood, T.E.; Smithen, D.A.; Crawford, S.M.; Cameron, T.S.; Thompson, A. “An Improved Method for the Synthesis of F-BODIPYs from Dipyrrins and Bis(dipyrrin)s” Organic Letters 2012, 14(8), 2158-61.
Mao, X.; Cao, B.; Wood, T.E.; Hurren, R.; Tong, J.; Wang, X.; Wang, W., Li, J.; Jin, Y.; Sun, W.; Spagnuolo, P.A.; MacLean, N.; Moran, M.F.; Datti, A.; Wrana, J.; Batey, R.A.; Schimmer, A.D. “A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway” Blood 2011, 117(6), 1986-97.
Wood, T.E.; Uddin, M.I.; Thompson, A. “The Synthesis and Properties of Dipyrrins” Chapter 39, Volume VIII The Handbook of Porphyrin Science, ed. Kadish, K.M.; Smith, K.M.; Guilard, R. World Scientific Publishing Co., Inc.: 2010.
Wood, T.E.; Dalili, S.; Simpson, C.D.; Sukhai, M.A.; Hurren, R.; Anyiwe, K.; Mao, X.; Suarez Saiz, F.; Gronda, M.; Eberhard, Y.; MacLean, N.; Ketela, T.; Reed, J.C.; Moffat, J.; Minden, M.D.; Batey, R.A.; Schimmer, A.D. “Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands” Molecular Cancer Therapeutics 2010, 9(1), 246-56.
Li, X.; Wood, T.E.; Sprangers, R.; Jansen, G.; Franke, N.E.; Mao, X.; Wang, X.; Zhang, Y.; Verbrugge, S.E.; Adomat, H.; Li, Z.H.; Trudel, S.; Chen, C.; Religa, T.L.; Jamal, N.; Messner, H.; Cloos, J.; Rose, D.; Navon, A.; Guns, E.; Batey, R.A.; Kay, L.E.; Schimmer, A.D. “Effect of non-competitive proteasome inhibition on Bortezomib resistance” Journal of the National Cancer Institute 2010 102(14) 1069-82.
Xu, G.W.; Ali, M.; Wood, T.E.; Wong, D.; MacLean, N.; Wang, X.; Gronda, M.; Skrtic, M.; Li, X.; Hurren, R.; Mao, X.; Venkatesan, M.; Beheshti Zavareh, R.; Ketela, T.; Reed, J.C.; Rose, D.; Moffat, J.; Batey, R.A.; Dhe-Paganon, S.; Schimmer, A.D. “The ubiquitin activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma” Blood 2010, 115(11), 2251-9.
Wood, T.E.; Dalili, S.; Hurren, R.; Gronda, M.; Simpson, C.D.; Suarez Saiz, F.; Eberhard, Y.; Minden, M.D.; Bilan, P.J.; Klip, A.; Batey, R.A.; Schimmer, A.D. “A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death” Molecular Cancer Therapeutics 2008, 7, 3546-55.
Wood, T.E.; Thompson, A. “Recent advances in the chemistry of dipyrrins” Chemical Reviews 2007, 107, 1831-61.
Updated: January, 2016
(photo credit: Cory Aronec Photography)