Dr. Charles S. Wong

image_200Professor and Canada Research Chair in Ecotoxicology

Adjunct Professor, University of Manitoba, Department of Environment and Geography
Adjunct Professor, University of Manitoba, Department of Chemistry


S.B. and S.M., Massachusetts Institute of Technology
Ph.D. , University of Minnesota

Phone: (204) 786-9335
Fax: (204) 775-2114
email: ch.wong@uwinnipeg.ca

Teaching Specialties:

CHEM 1111 Introduction to the Chemical Properties of Matter
ENV 2604/3 Environment and Health
CHEM/ENV 3611/3 Environmental Toxicology
CHEM 4303/3 Analytical Separations
CHEM 7450 Environmental Organic Chemistry (graduate)
CHEM 7450 Environmental Toxicology (graduate)

Research Interests:

My research interests are in the area of environmental chemistry, and focus on elucidating the fate, behavior, and effects of anthropogenic compounds in the environment. A thorough understanding of how chemical pollutants move, react, and persist in the environment is crucial for finding solutions to the risks they may pose to the public, to wildlife, and to environmental resources. Of particular interest are chemicals that are widely produced and released as a result of human activity, and/or chemicals that bioaccumulate up aquatic and terrestrial food webs that are globally distributed from long-range transport.

A major area of research is the environmental chemistry of chiral organic pollutants. Many xenobiotic compounds are optically active: both legacy chemicals such as DDT, chlordanes and other chlorinated pesticides, and some PCB congeners; as well as current-use chemicals such as modern agrochemicals, pharmaceuticals and personal care products, and metabolites. Enantiomers of these chemicals generally undergo the same physical and chemical processes in the environment, but may have different biochemical and toxicological effects due to differential interactions with other chiral molecules (i.e., enzymes in living organisms).We have developed analytical techniques to measure enantiomeric composition of chiral pollutants in complex environmental compartments (e.g., natural waters, sediments, foods, biological tissues, waste streams) via chiral GC, multidimensional GC, HPLC, and capillary electrophoresis, usually coupled to mass spectrometric (MS or tandeom MS) detection for sensitivity and selectivity. These techniques are applied both in laboratory and field settings to understand stereoselective biotransformation and toxicological effects of chiral chemicals in the environment, and implications these may have on the ultimate fate of persistent pollutants.Another research area is the environmental occurrence and fate of emerging classes of environmental pollutants, including current-use agrochemicals, fluorinated surfactants, pharmaceuticals, personal care products, pollutant metabolites, and engineered nanomaterials. These chemicals are often heavily used in household or industrial applications, and may survive treatment when they are disposed and thus enter the environment. In general, little is known about the fate and transport of many such compounds, or of toxic effects.Our research interests for emerging pollutants include development of new and better techniques to measure these chemicals at trace concentrations of parts-per-trillion and below (e.g., passive sampling, microextraction) in very complex environmental matrices such as wastewaters, surface waters, and biological tissues. We also apply these techniques to understand environmental processes and effects of these compounds.

Selected Publications:

Rhu MH, Jha A, Ojo OO, Mahood TH, Basu S, Detillieux KA, Nikoobakht N, Wong CS, Loewen M, Becker AB, Halayko AJ (2014).  Chronic exposure to perfluorinated compounds:  Impact on airway hyperresponsiveness and inflammation.  Am J Physiol Lung Cell Mol Physiol, in press http://dx.doi.org/10.1152/ajplung.00100.20142014

Challis JK, Hanson ML, Friesen KJ, Wong CS (2014).  A critical assessment of the photodegradation of pharmaceuticals in aquatic environments:  Defining our current understanding and identifying knowledge gaps.  Environ Sci: Processes Impacts 16, 672-696 (invited).  http://dx.doi.org/10.1039/C3EM00615H

Cardinal P, Anderson JC, Carlson JC, Low JE, Challis JK, Beattie SA, Bartel CN, Elliott AD, Montero OF, Lokesh S, Favreau A, Kozlova T, Knapp CW, Hanson ML, Wong CS (2014).  Macrophytes may not contribute significantly to removal of nutrients, pharmaceuticals, and antibiotic resistance in model surface constructed wetlands.Sci Total Environ 482-483, 294-304.  http://dx.doi.org/10.1016/j.scitotenv.2014.02.095

Bews HJ, Carlson JC, Jha A, Basu S, Halayko AJ, Wong CS (2014).  Simultaneous quantification of simvastatin and simvastatin hydroxy acid in blood serum at physiological pH by ultrahigh performance liquid chromatography-tandem mass spectrometry (UHPLC/MS/MS).  J Chromatogr B 947–948, 145-150http://dx.doi.org/10.1016/j.jchromb.2013.12.030

Lu Z, Fisk AT, Kovacs K, Lydersen C, McKinney M, Tomy GT, Rosenburg B, McMeans BC, Muir DCG, Wong CS (2014).  Temporal and spatial variation in polychlorinated biphenyl chiral signatures of the Greenland shark (Somniosus microcephalus) and its arctic marine food web.  Environ Pollut 186, 216-225. http://dx.doi.org/10.1016/j.envpol.2013.12.005

Lu Z, Kania-Korwel I, Lehmler H-J, Wong CS (2013).  Stereoselective formation of mono- and di-hydroxylated polychlorinated biphenyls by rat cytochrome P450 2B1.  Environ Sci Technol 47, 12184–12192. http://dx.doi.org/10.1016/j.chemosphere.2013.05.004

Challis JK, Carlson JC, Friesen KJ, Hanson ML, Wong CS (2013).  Aquatic photochemistry of the sulfonamide antibiotic sulfapyridine.  J Photochem Photobiol A 262, 14-21http://dx.doi.org/10.1016/j.jphotochem.2013.04.009

Anderson JC, Carlson JC, Low JE, Challis JK, Wong CS, Knapp CW, Hanson ML (2013).  Performance of a
constructed wetland in Grand Marais, Manitoba, Canada:  Removal of nutrients, pharmaceuticals, and antibiotic resistance genes from municipal wastewater.  Chem Cent J 7, 54 (invited). http://dx.doi.org/10.1186/1752-153X-7-54

Carlson JC, Challis JK, Hanson ML, Wong CS (2013).  Stability of pharmaceuticals and other polar organic compounds stored on Polar Organic Chemical Integrative Samplers and solid phase extraction cartridges.  Environ Toxicol Chem 32, 337-344.http://dx.doi.org/10.1002/etc.2076

Carlson JC, Anderson JC, Low JE, Cardinal P, MacKenzie SD, Beattie SA, Challis JK, Bennett RJ, Meronek SS, Wilks RPA, Buhay WM, Wong CS, Hanson ML (2013).  Presence and hazards of nutrients and emerging organic micropollutants from sewage lagoon discharges into Dead Horse Creek, Manitoba, Canada.  Sci Total Environ 445-446, 64-73.  http://dx.doi.org/10.1016/j.scitotenv.2012.11.100