Natural Products – Leads for Pharmaceutical Industry

COURSE SYLLABUS

Department of Chemistry
The University of Winnipeg

Natural Products – Leads for Pharmaceutical Industry

Class Meetings:                     Wednesday 6-9 PM
Classroom Location:            TBA

Instructor:                             Athar Ata     

                                                Office Hours: Monday-Friday (14:00-16:00)

Required Course Materials:                       

No formal text is required. Material from recent literature will be distributed and discussed in the class

GRADING:

Marks Break-Down:

Term Test        (TBA)           25
Assignments                         30
Final Exam      (TBA)          45
100%

COURSE OUTLINE:

  • Introduction primary and secondary metabolites
  • Classes of Natural Products : Alkaloids, terpenoinds and aromatic compounds
  • Pharmaceutical industry and Natural Products
  • Biosynthesis of Natural Products: Theories, Biological and Organic Reactions Mechanism
  • Aromatic polyketides
  • Aromatic polyketides
  • Macrolide polyketides
  • Plant polyketides and bacterial type III PKSs
  • Shikimic acid pathway
  • Phenylpropanoids and lignin
  • Terpenoids
  • Terpene cyclases
  • Non-ribosomal peptide synthesis
  • Alkaloids – Orn/Lys-based
  • Alkaloids – Phe/Tyr/Trp-based
  • Engineered biosynthesis
  • Elucidation of Biosynthesis of selected compounds (terpenoids, polyketides and alkaloids)
  • Biotechnological methods to produce natural product